Alpha GPC (L-alphaglycerylphosphorylcholine, also known as choline alfoscerate) is a phospholipid found concentrated in nerve membranes. In the brain, Alpha GPC supports brain function and learning processes by directly increasing the synthesis and secretion of acetylcholine. Alpha GPC protects neurons and improves signal transmission by serving as a precursor to membrane phospholipids. Strengthening the membranes encasing the neurons increases the speed and accuracy with which information is transmitted, reducing timing delays and reducing distortion of signals. Sensory distortion and timing delays are believed to be the amongst the root causes of autism. The better neurologically connected, the fewer the symptoms.
Made from soy lecithin, Alpha GPC is extremely well absorbed and crosses the blood brain barrier. As a dietary supplement Allphpha GPC boosts mental performance in healthy young people, as shown by three double-blind trials. In trials on middle aged subjects, GPC improved several physiologic measures of mental performance: reaction time, visual evoked potential, and EEG delta slow waves. GPC reaches extremely high concentrations within our cells, and is abundant in mother's milk, suggesting it is important in early childhood development. GPC can revitalize the aging brain, facilitating growth hormone (GH) release and boosting nerve growth factor actions.
Alpha GPC and Aging
In the elderly, GPC improves mental performance and provides noticeable revitalization. In 11 human trials with 1,799 patients, memory, attention, and other cognitive measures improved. So did mood (including irritability and emotional lability), and patients often developed renewed interest in relatives and friends. GPC was well tolerated, and generated no bad drug interactions. A large trial on elderly subjects with memory challenges published in 2003 concluded GPC had significant benefits for these individuals.
Circulatory deprivation or surgery can challenge healthy brain function. GPC can speed recovery and support improved quality of life. In four trials with GPC on 2,804 subjects who experienced difficulties under these circumstances, up to 95% showed good or excellent improvement. GPC consistently improved space-time orientation, degree of consciousness, language, motor capacity, and overall quality of life. The investigators concluded GPC offered marked benefits, with an excellent benefit-to-risk profile. Up to half of patients who survive bypass surgery experience problems with memory and other mental performance. A double-blind trial conducted with bypass survivors for six months determined that the GPC group had no remaining memory deterioration, while the placebo group failed to improve.
GPC Works Through Multiple Mechanisms
GPC supports human health through a variety of mechanisms:
1. It helps keep choline and acetylcholine available to the tissues. Choline is an essential nutrient and GPC appears to be the body's main choline reservoir. GPC in mother's milk represents the baby's main source of dietary choline.
Acetylcholine (ACh) is an important substance employed extensively throughout the body. ACh is a major brain transmitter; the motor nerves use ACh to drive the skeletal ("voluntary") muscles; the autonomic nervous system uses it to pace all the organs. ACh is also central to mental and physical endurance, and mind-body coordination.
2. GPC is a major cell-level protectant, not as another antioxidant but in pivotal roles of osmotic pressure regulator and metabolic antitoxin. GPC for osmotic regulation can reach very high concentrations in the kidney, bladder, liver, brain, and other organs. As metabolic protectant, GPC shields proteins against urea buildup.
3. GPC is a major reservoir for cell membrane omega-3 phospholipids. These substances are the major building blocks for cell membranes. Enzymes couple GPC with the omega-3 fatty acid DHA, to make the phospholipid PCDHA. This makes membranes especially fluid, enabling membrane proteins to perform with better efficiency.
GPC produces PC-DHA in the skeletal muscles, wherein fluidity is essential for contraction. Muscles that function abnormally can show GPC deficiency.
GPC: Nutrient for All Ages
GPC is unmatched for its support of active living and healthy aging. I
GPC's ample presence in human mother's milk suggests it could be conditionally essential. By supporting mental integrity, mind-body integration, the autonomic system, and the body's other organs, GPC enhances the active lifestyle. GPC is remarkable nutritional support for optimal health at any age.
Dosing, Safety, Tolerability, Compatibility
Oral intake of GPC in the clinical trials was usually 1,200 milligrams (mg) per day, taken early in the day on an empty stomach. A reasonable dietary supplementation regimen is 1200 mg/day, taken in divided doses and between meals for 15-30 days, and thereafter 600 mg/day for maintenance. Symptomatic subjects can take 1200 mg/day until adequate improvement is achieved. Young, healthy subjects may experience benefit from daily intakes as low as 300 milligrams.
GPC is very safe, being compatible with vitamins and nutrients and with pharmaceuticals. In clinical trial comparisons, GPC's benefits surpassed the nutrients acetylcarnitine and CDP-choline.
ngredients: 1 preservative-free gelcap provides the following percentages of the Daily Value:
* No Daily Value has been established for this ingredient
DOSAGE: The recommended adult dosage is as a dietary supplement take 1 gelcap daily away from food, or as directed by a health care professional.
Other Ingredients: Cellulose, dicalcium phosphate, silicon
dioxide, stearic acid (vegetable source) and magnesium stearate
(vegetable source). Capsule consists of hydroxypropylmethylcellulose.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.