is the hormone that promotes sleep at night and during the day
converts to Seratonin, which elevates mood and promotes mental
alertness. I would recommend not using this every 2-3 nights instead
of every night as the brain can acclimate to introduced neurotransmitters
and then produce less of it over time. Our convenient spray includes both
Melatonin and B6 which work together to promote calm and sleep. The
soy-based liposomes that enclose the Melatonin and B6 make this spray
significantly more absorbable.
ABOUT MELATONIN - AND SLEEP
Melatonin is a powerful hormone secreted by the pineal gland located in
the brain. Its secretion is stimulated by the dark and inhibited by light,
and it aids in the regulation of the body’s circadian rhythm, or
sleep-wake cycle. Research done at the Wurtman Lab at M I T has shown that
melatonin tells us when to fall asleep and helps us remain asleep.
Research at Wurtman also showed that as we age we make dramatically less
melatonin. “Older people often complain of insomnia, particularly
difficulty in staying asleep, and in falling back to sleep after they
awaken at night. Doses of melatonin which give them "youthful"
blood melatonin levels correct this insomnia.” (1)
A POWERFUL ANTIOXIDANT
The decades-long research of Dr. Russel Reiter found that melatonin is
much more than a sleep enhancer and an unequalled remedy for jet lag. He
states: “Right now…melatonin in your blood is preventing the oxidation
of LDL cholesterol, the “bad” cholesterol that can clog your arteries.
Melatonin in your brain is safeguarding your irreplaceable neurons from
free-radical attack. Melatonin in the fluid within your eyes is helping to
prevent …cataracts. Melatonin in the lining of your gut is reducing your
risk of ulcers. Melatonin is the most potent, versatile antioxidant.”
AUTISM SPECTRUM DISORDER
In this article, researchers from Vanderbilt University describe their
experience using melatonin to treat insomnia, a common sleep concern, in
children with autism spectrum disorders....There was no reported increase
in seizures after starting melatonin in children with pre-existing
epilepsy and no new-onset seizures... "Melatonin appears to be a safe
and well-tolerated treatment for insomnia in children with autism spectrum
A mouse study involved two groups of mice, 19 months old, that were
housed, fed and treated identically, except that each evening one group
received a trace amount of melatonin in their drinking water. Five months
into the study, the plain water mice had a slower pace, were losing
patches of fur, were humped over and were losing weight; they were aging.
The “melatonin mice” were glossy and plump. Eventually the plain water
mice lived an average of 752 days, typical for this strain of mouse. The
mice that had been given the melatonin-laced water lived an average 20%
longer, to 931 days. (3)
Dr. Reiter believes that because melatonin is a vital antioxidant that
declines precipitously with age, its gradual loss could explain why aging
accelerates over time. (4)
A six-month study of melatonin and menopausal women was carried out at a
clinic in Rome, Italy. There were no side effects reported in the use of
melatonin in this study. They asserted that “the six-month treatment
with melatonin produced a remarkable and highly significant improvement of
thyroid function, positive changes of gonadotropins towards more juvenile
levels, and lessening of menopause-related depression.” (5)
MELATONIN AND THE MOUTH
Melatonin may play a role in protecting the oral cavity from tissue damage
that is due to oxidative stress, and it may contribute to the regeneration
of alveolar bone through the stimulation of type I collagen fiber
production ... (12)
Thus, Melatonin could be used therapeutically for instance, locally, in
the oral cavity damage of mechanical, bacterial, fungal or viral origin,
in post-surgical wounds caused by tooth extractions and other oral
surgeries and, in helping bone formation in various auto-immunological
disorders such as Sjorgen syndrome, in periodontal diseases, and in oral
It was the purpose of this study to examine the relationship between
periodontal diseases and melatonin level. Patients with periodontal
disease had significantly lower plasma and saliva melatonin levels than
healthy control patients. (14)
MELATONIN: MANY STUDIES, A FEW MENTIONED HERE
* Alzheimer’s disease: Melatonin supplementation
improves sleep, and slows down the progression of cognitive impairment in
Alzheimer’s patients. (7)
* Blood-Brain Barrier: A major advantage of melatonin is
that it can easily cross the blood brain barrier and enter cells and
subcellular compartments. (9)
* Breast cancer: Women with breast cancer tend to have
lower levels of melatonin than those without the disease. In addition,
laboratory experiments have found that low levels of melatonin stimulate
the growth of certain types of breast cancer cells, while adding melatonin
to these cells inhibits their growth. (11)
* Heavy Metals: It has been shown to be protective
against the oxidation stress toxicity of some heavy metals. (10)
* Mood Disorders: Not only the levels but also the timing
of melatonin secretion is altered in bipolar affective disorder and in
patients with seasonal affective disorder (SAD) (8)
DRUGS THAT DEPLETE MELATONIN
Studies have shown that these drugs deplete melatonin: aspirin, ibuprofen,
beta-blockers, calcium channel blockers, sleeping pills and tranquilizers.
(2) Reiter, Russel J. Melatonin, Bantam Books, New York, N.Y., 1995, 6.
(3) Maestroni, GJ et al, Pineal Melatonin, Its Fundamental
Immunoregulatory Role in Aging and Cancer, Ann NY Acad Sci 1988; 521:
(4) Reiter RJ, Oxidative Processes and Antioxidative Defense Mechanisms in
the Aging Brain. .FASEB J. 1995 Apr; 9(7):526-33.
(5) Bellipanni, Giulio, Effects of Melatonin in Perimenopausal and
Menopausal Women: ….,” Ann N Y Acad Sci, 2005; 1057: 393-402.
(6) Andersen IM, et al. Melatonin for Insomnia in Children With Autism
Spectrum Disorders. J Child Neurol. 2008 Jan 8 [Epub ahead of print]
(7) Wang JZ. Role of melatonin in Alzheimer-like Neurodegeneration. Acta
Pharmacol Sin, 2006 Jan; 27(1): 41-9.
(8) Srinivasan V et al, Melatonin in Mood Disorders, World J Biol
Psychiatry. 2006; 7 (3):138-51.
(9) Indian J Physiol Pharmacol. 2003 Oct; 47(4):373-86
(10) Curr Med Chem. 2005; 12(10):1161-208
(11) Cos S, Sanchez-Barcelo EJ. Melatonin, experimental basis for a
possible application in breast cancer prevention and treatment. Histo
Histopath . 2000;15:637-647.
(12) Cutando A et al, Melatonin: potential functions in the oral cavity.J
Periodontol. 2007 Jun;78(6):1094-102.
(13) Czesnikiewicz-Guzik M, et al. Melatonin and its role in oxidative
stress related diseases of oral cavity.J Physiol Pharmacol. 2007 Aug;58
(14) Gómez-Moreno G, et al. Melatonin expression in periodontal disease.J
Periodontal Res. 2007 Dec;42(6):536-40.
spray has .5 mg of melatonin.
Vitamin B6 - Has a calming effect on the nervous system
Melatonin - Synthetic
Stevia - A natural sweetener with an insignificant effect on blood
Lecithin - The liposomes in ReadiSorb Melatonin Spray are derived from
lecithin. The lecithin is derived from oil, not protein, extracted from
Glycerin - Glycerin is used as a sweetener and preservative. It
supports the stability of the liposomes and allows for the extended shelf
life. Glycerin is a normal product of fat metabolism and is readily
converted to glucose for metabolism.
Natural Fruit Flavor
Citric Acid - Citric acid is used as a flavoring and preservative.
Potassium Sorbate - A natural material used as a preservative to
prevent yeast and mold growth. It is a form of sorbic acid, a naturally
occurring fatty acid which is easily metabolized in the body. Potassium
sorbate is used to preserve wine, baked goods and cheese.
Directions for use: Shake bottle, spray under tongue or on inside of
cheek, hold for 20 seconds and swallow. If possible, take 20 - 30
minutes before bedtime. There are approximately 84 sprays per bottle.